Duloxetine (Cymbalta®)

This is a handout explaining that Duloxetine is a medication that works by increasing the brain levels of two chemical messengers, norepinephrine and serotonin, that help to lessen the intensity of incoming pain signals.  It is used to treat pain from damaged nerves, fibromyalgia, chronic low back pain, and knee pain due to osteoarthritis. Duloxetine is also used to treat depression and anxiety.